Cortiment®MMX is an oral dosage form of the corticosteroid budesonide with a local effect in the intestines. The tablets with MMX technology are characterized by matrix polymers coated with a gastro-resistant film that releases the budesonide at a controlled rate only in the lower part of the intestine (at pH above 7) at a controlled rate.
The exact mechanism of action of budesonide in the treatment of UC and MC is not fully understood. In general, budesonide inhibits many inflammatory processes. At doses clinically equivalent to prednisolone, Cortiment®MMX provides significantly less hypothalamic-pituitary-adrenal (HPA) axis suppression and has less impact on inflammatory markers.
How Cortiment works explained.
In this animation video the operation of Cortiment®MMX is explained.
Product information
Content of packaging Cortiment®MMX.
Cortiment®MMX is supplied in blister packs containing 30 round gastro-resistant tablets.
In the package, the patient receives the following:
- 30 gastro-resistant tablets
- Package Leaflet (see also Downloads)
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Cortiment®MMX does not need to be kept refrigerated.
A Cortiment®MMX tablet is taken orally in the morning with a glass of water, with or without food. The tablet should be swallowed whole (without chewing, breaking, crushing) to avoid damage to the extended-release film coating.
Cortiment®MMX tablets contain lecithin (soybean oil). If a patient is hypersensitive to peanuts or soya, this medicinal product should not be used.
Adults and the elderly.
For induction of remission in ulcerative colitis and microscopic colitis, the recommended daily dose is one 9 mg tablet in the morning for up to 8 weeks. When stopping treatment, it may be helpful to gradually reduce the dose. No special dose adjustment is recommended for use in the elderly. However, experience with the use of Cortiment®MMX for the elderly is limited.
Paediatrics.
No data are available on the effect in children (aged 6-18 years). Therefore, the use of this medicinal product in pediatric patients is not recommended until more data is available1.
Source:
1 SmPC Cortiment®MMX tablets. Last modified on September 2, 2020.
Depending on the individual response to a treatment, a doctor may decide in consultation with the patient to combine the use of Cortiment®MMX tablets with other medicines. The tapering schedule below is an example of a drug combination therapy for IBD in which different drugs are combined.
Combination drug therapy in ulcerative colitis.
Klik hier om het therapieschema te downloaden.
We have several materials about Cortiment®MMX available. These can be downloaded directly below.
| Product | Videos | Brochure | SmPC | Instruction leaflet |
| Cortiment®MMX | Video tutorial Cortiment®MMX – Watch video | Brochure “Evidence based prescribing” – Download | Download SmPC | Download insert |
Request materials.
Would you like to pass on the brochure or tear block to your patients? All materials can be requested from us free of charge. You will then receive this automatically.
