In patients with chronic inflammatory bowel disease, there is an abnormal production of especially cytokine and leukotrienes and an increased migration of leukocytes. Mesalazine may have an inhibitory effect on these processes.
Mesalazine explained.
In this animation video the effect of mesalazine is explained.
Product information.
Content of packaging Pentasa® Suppository.
The Pentasa® suppositories are each individually wrapped in foil and contain 1 gram of mesalazine per suppository as the active ingredient. The package contains 28 finger protectors to insert the suppositories hygienically.
In the package, the patient receives the following:
- 28 suppositories (1 gram per suppository)
- 28 finger guards
- Package Leaflet (see also Downloads)
- Updated information via the QR code on the packaging
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Pentasa® Suppository does not require refrigerated storage.
The Pentasa® Suppository should be inserted through the anus. To prevent the suppository from leaving the body prematurely through the stool after administration, it is recommended to have a stool before using the suppository. For patients with a very sensitive anus, it is recommended to smooth the suppository with a little water before insertion.
After insertion, the suppositories are intended to remain in the intestine for as long as possible. It is, therefore, generally recommended to take the suppositories in the evening immediately before going to sleep.
We have an instruction video and brochure available to properly use the Pentasa® Suppository. See the ‘Downloads’ tab for all available materials.
In deze instructievideo wordt het juiste gebruik van Pentasa® Zetpil uitgelegd.
The dosage of the Pentasa® Suppository should be adjusted to the severity of the disease.
Generally, one suppository is recommended 1-2 times a day for adults and older children.
For daily dosing, taking the suppository in the evening is recommended before going to sleep. With a twice-daily dose, it is wise to insert the second suppository early in the morning, for example, or else in the morning after going to the toilet.
There is little experience and only limited documentation on an effect in children1.
1 SmPC Pentasa® Enema. Last modified on March 22, 2021.
We have several materials available about Pentasa® Suppository. These can be downloaded directly below.
| Product | Videos | Brochure | SmPC | Instruction leaflet |
| Pentasa® Suppository | Instruction video Pentasa® Suppository – Watch video | Brochure “Instructions for use Pentasa® Suppository” – Download | Download SmPC | Download insert |
Request materials.
Would you like to pass on the brochure or tear block to your patients? All materials can be requested from us free of charge. You will then receive this automatically.
