IBD onStress
Stress increases gastrointestinal permeability and modifies gut flora to promote the pathophysiology of IBD. This is done utilizing corticotropin-releasing factor (CRF) and urocortin. These neuromediators then act on G protein-coupled CRF1 and CFR2 receptors in the brain and gastrointestinal tract.
CRF2 receptors are involved in the disruption of intestinal permeability. Mastocytes in the mucosa release CRF and urocortin, which bind to CRF1 and CRF2 in the same lamina propria. As a result, these mastocytes release cytokines and other anti-inflammatory mediators. CRF also increases gut permeability by causing mast cells to release tumour necrosis factor-alpha and proteases. Targeted treatment at CRF receptors with selective antagonists to inhibit mast cell activation is a therapeutic option for chronic inflammatory disorders exacerbated by stress.
Stress reduction may have a positive effect on inflammatory markers. A study was recently published1 showing that mindfulness as an intervention in addition to drug treatment positively influences inflammatory markers CRP and FC.
The editorial board of IBD onPlay has compiled this animation based on clinical insights for practicality in combination with recent insights from the literature, including guidelines. The content is intended for educational and informational purposes and is not intended to replace guidelines or provide unambiguous advice in individual situations. No part of these animations may be copied in any way without the prior written permission of the editorial board. These animations were created in collaboration between the editorial board and FourCorners and made possible by Ferring B.V.
Sources:
- Rafael González-Moret et al. 2020. The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomized controlled trial. Scientific Reports. 10;6071.
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