onAdherence

Non-adherence occurs in up to 45% of IBD patients and is specified with improved improvements and relapse rates. Non-adaptive treatments can be adapted to regimen change and unintentional change. The type of non-adherence can have implications for clinical outcomes and can have unique drivers.

Unfortunately, there is no consistent predictor of non-adherence. Some studies have identified younger age, full-time employment, shorter illness, type of treatment, and psychological factors (such as emotional solid response and loss of response to therapy) as possible risk factors. Non-adherence in IBD is difficult for doctors to identify. To date, no simple and sustainable intervention has improved adherence.

The editorial board of IBD onPlay has compiled this animation based on clinical insights for practicality in combination with recent insights from the literature, including guidelines. The content is intended for educational and informational purposes and is not intended to replace guidelines or provide unambiguous advice in individual situations. No part of these animations may be copied in any way without the prior written permission of the editorial board. These animations were created in collaboration between the editorial board and FourCorners and made possible by Ferring B.V.

Sources

• Jonathan Perry, et al. Non-adherence and disability in IBD. Intest Res 2018;16(4):571-578.
• Selinger CP, Robinson A, Leong RW. Clinical impact and drivers of non-adherence to maintenance medication for inflammatory bowel disease. Expert Opin Drug Saf. 2011;10:863–870
• Jackson CA, Clatworthy J, Robinson A, Horne R. Factors associated with non-adherence to oral medication for inflammatory bowel disease: a systematic review. Am J Gastroenterol. 2010;105:525–539.
• Ediger JP, Walker JR, Graff L, et al. Predictors of medication adherence in inflammatory bowel disease. Am J Gastroenterol. 2007;102:1417–1426
• Van der Have M, Oldenburg B, Kaptein AA, et al. Non-adherence to anti-TNF therapy is associated with illness perceptions and clinical outcomes in outpatients with inflammatory bowel disease: results from a prospective multicentre study. J Crohns Colitis. 2016;10:549–555.
• Trindade AJ, Ehrlich A, Kornbluth A, Ullman TA. Are your patients taking their medicine? Validation of a new adherence scale in patients with inflammatory bowel disease and comparison with physician perception of adherence. Inflamm Bowel Dis. 2011;17:599–604.